Development of new therapies for metastatic pancreatic cancer: are they better than FOLFIRINOX?
نویسندگان
چکیده
منابع مشابه
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer.
BACKGROUND Data are lacking on the efficacy and safety of a combination chemotherapy regimen consisting of oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) as compared with gemcitabine as first-line therapy in patients with metastatic pancreatic cancer. METHODS We randomly assigned 342 patients with an Eastern Cooperative Oncology Group performance status score of 0 or 1 (on...
متن کاملPancreatic cancer and FOLFIRINOX: a new era and new questions
FOLFIRINOX (FFX) was introduced to clinical practice in 2010 following publication of the PRODIGE 4/ACCORD 11 study, which compared this novel regimen to gemcitabine in metastatic pancreatic cancer. Median overall survival, progression-free survival, and objective responses were all superior with FFX and there was improved time to definitive deterioration in quality of life. Despite initial con...
متن کاملPhase II study of FOLFIRINOX for chemotherapy-naïve Japanese patients with metastatic pancreatic cancer
The FOLFIRINOX combination of chemotherapy drugs had not been fully evaluated for Japanese pancreatic cancer patients. Therefore, we carried out a phase II study to examine the efficacy and safety of FOLFIRINOX in chemotherapy-naïve Japanese patients with metastatic pancreatic cancer. FOLFIRINOX (i.v. infusion of 85 mg/m(2) oxaliplatin, 180 mg/m(2) irinotecan, and 200 mg/m(2) l-leucovorin, foll...
متن کاملCost-effectiveness of folfirinox for first-line treatment of metastatic pancreatic cancer.
BACKGROUND The accord 11/0402 trial demonstrated that folfirinox (5-fluorouracil, leucovorin, irinotecan, oxaliplatin) is significantly more efficacious than gemcitabine monotherapy in the first-line treatment of metastatic pancreatic cancer (mpc). The present study assessed the cost-effectiveness of first-line folfirinox compared with first-line gemcitabine for public payers in Canada. METHO...
متن کاملNew therapies for pancreatic cancer: current standard.
With regard to resectable disease, two recent phase III randomized trials showed that postoperative chemotherapy, either 5fluorouracil or gemcitabine, significantly prolongs overall and disease-free survival with respect to observation alone [1, 2]. A Radiation Therapy Oncology Group (RTOG) phase III randomized trial showed significantly better survival after gemcitabine chemotherapy with respe...
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ژورنال
عنوان ژورنال: ESMO Open
سال: 2019
ISSN: 2059-7029
DOI: 10.1136/esmoopen-2019-000537